Perspective in predicting the effect of pleurodesis in the treatment of malignant pleural effusions.

Content Provider	Semantic Scholar
Author	Habal, Petr Omran, Nedal Kovacicova, K. Chek, James Lago Jankovičová, Karolína Manďák, Jiří
Copyright Year	2015
Abstract	BACKGROUND Pleurodesis with talc has been used for many years. No objective criteria of inflammatory symptoms are known in order to use them to predict the effect of therapy and selection of patients. PURPOSE OF THE STUDY To objectify the course of local inflammatory changes in the pleural cavity, quantify their dynamics in a clinically used procedure, and to determine specific predictors of inflammation as perspective markers of selection of patients suitable for talcage. MATERIAL AND METHOD A total of 114 patients were retrospectively divided into Group A (n1 = 98) of patients without relapse and Group B (n2 = 16) of patients with relapse of exudate. The need for repeated thoracic punctures or drainages over the course of a 12-month monitoring period was the criterion of treatment failure. RESULTS The groups were not different as for the baseline values of sTLR-2 (p₀ = 0.638). Group A showed a marked growth during the monitoring period in 2 hours following talcage (p₂= 0.002) and in 24 hours (p24 = 0.016). Group B showed higher sCD-163 levels (p0 < 0.001). The initial sTREM-1 values and those after two hours were similar in both groups (p0 = 0.146; p2 < 0.0641). In 24 hours, Group A had markedly higher values (p24 < 0.001). CONCLUSION The sTLR-2, sCD-163 and sTREM-1 values can be prospectively determined. High sCD-163 values predict unsuitable selection of a candidate for talcage. The degree of inflammatory response can be evaluated using sTLR-2 or sTREM-1. Talcage using an inserted thoracic drain can be repeated at low levels. The cost of ELISA examination is approximately 18 euros (Tab. 1, Fig. 4, Ref. 20).
Starting Page	95
Ending Page	108
Page Count	14
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.elis.sk/download_file.php?product_id=4241&session_id=1b34c28ec4906341fc97d77b197c5e4f
PubMed reference number	25924636v1
Volume Number	116
Issue Number	5
Journal	Bratislavske lekarske listy
Language	English
Access Restriction	Open
Subject Keyword	Body Fluid Discharge Chest Tubes Clinical act of insertion Dental caries Enzyme-Linked Immunosorbent Assay Exudate Metabolic Process, Cellular Patients Pleura Pleural Effusion, Malignant Pleural effusion disorder Pleurodesis Puncture wound Talc Thoracic Outlet Syndrome Tissue membrane inflammatory response
Content Type	Text
Resource Type	Article