Tumorigenesis and Neoplastic Progression CSR 1 Suppresses Tumor Growth and Metastasis of Prostate Cancer

Content Provider	Semantic Scholar
Author	Yu, Guo-Ying Tseng, George C. Yu, Yan Ping Gavel, Tim Nelson, Joel B. Wells, Alan Michalopoulos, George Kokkinakis, Demetrius M. Luo, Jianhua
Copyright Year	2006
Abstract	Prostate cancer is frequent among men over 45 years of age, but it generally only becomes lethal with metastasis. In this study, we identified a gene called cellular stress response 1 (CSR1) that was frequently down-regulated and methylated in prostate cancer samples. Survival analysis indicated that methylation of the CSR1 promoter, and to a lesser extent downregulation of CSR1 protein expression, was associated with a high rate of prostate cancer metastasis. Forced expression of CSR1 in prostate cancer cell lines DU145 and PC3 resulted in a twoto threefold decrease in colony formation and a 10-fold reduction in anchorage-independent growth. PC3 cells stably expressing CSR1 had an average threefold decrease in their ability to invade in vitro. Expression of CSR1 in PC3 cell xenografts produced a dramatic reduction (>8-fold) in tumor size, rate of invasion (0 versus 31%), and mortality (13 versus 100%). The present findings suggest that CSR1 is a potent tumor suppressor gene. (Am J Pathol 2006, 168:597–607; DOI: 10.2353/ajpath.2006.050620)
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ajp.amjpathol.org/cgi/reprint/168/2/597.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article