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Relationships between genotypes and phenotypes in natural populations of the European flounder (Platichthys flesus) under different types of contamination in estuaries
| Content Provider | Semantic Scholar |
|---|---|
| Author | Marchand, Jonathan Quiniou, Louis Laroche, Jean |
| Copyright Year | 2013 |
| Abstract | The integration of population genetics in ecotoxicology may be pertinent i) to detect possible differential physiological capacities or performances between individuals carrying particular alleles or genotypes, and ii) to explain their potential resistant or sensitive characters, sometimes resulting in increasing or decreasing frequencies in contaminated systems.1 Different studies were conducted on the genetic and physiological responses of the European flounder (Platichthys flesus) to pollution stress, especially in estuaries along the Atlantic coast of France.2,3 The authors highlighted that: i) particular alleles and genotypes (allozyme data) may be likely influenced (indirectly or directly) by chemical stress; ii) fish carrying these alleles or genotypes displayed higher DNA integrity over the whole contaminated populations. In addition, relationships between genotypes and phenotypes highlighted specific trends related to pollutant estuarine characteristics. In a more recent study,4 new DNA markers were explored in P. flesus; cDNA and genomic sequences of the genes encoding the glyceraldehyde-3-phosphate-deshydrogenase (GAPDH), the cytosolic creatine kinase(CK), the prostaglandin D synthase (PGDS) and the betaine homocysteine methyl-transferase (BHMT) were characterized.4 The tumor suppressor p53 gene was also considered in this study, the gene structure being already described. The exploration of the genetic polymorphism was carried out on several flounder populations along the French coast. The frequency of the p53-A allele was shown to be higher in contaminated populations (collected in the Gironde, Loire, Seine and Vilaine estuaries) compared to a reference site (Ster estuary), this increase ranging from 12.4% to 13.7%.4 In the Vilaine estuary, mean increases of 10% in BHMT-A and PGDS-A allele frequencies were also observed compared to the Ster estuary.4 Globally, the analysis of genetic diversity within populations and genetic differentiation suggested that the patterns of genetic structuration detected for flounders were probably more linked to local selection acting on the candidate genes than to the consequence of possible isolations by distance, or different histories of colonization.4 In the present report, new investigations were conducted on flounder populations stemming from environmentally contrasted estuaries. Our main objective was to confirm the possible selective effects of the contaminant on the candidate genes (GAPDH, CK, PGDS, BHMT, p53) by exploring the couplings between genotypes and phenotypes in the field. Journal of Xenobiotics 2013; volume 3(s1):e14 |
| Starting Page | 14 |
| Ending Page | 14 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| DOI | 10.4081/xeno.2013.s1.e14 |
| Volume Number | 3 |
| Alternate Webpage(s) | https://www.pagepressjournals.org/index.php/xeno/article/download/xeno.2013.s1.e14/1668 |
| Alternate Webpage(s) | https://doi.org/10.4081/xeno.2013.s1.e14 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
