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Efeitos da suplementação com melatonina e do treinamento físico aeróbio sobre o perfil metabólico de ratos diabéticos induzidos por estreptozotocina.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Melo, Ronaldo M. |
| Copyright Year | 2012 |
| Abstract | Melo RM. Effects of melatonin supplementation and physical training on metabolic profile in diabetic rats induced by streptozotocin. [Ph D. thesis (Human Physiology)] São Paulo: Instituto de Ciências Biomédicas da Universidade de São Paulo; 2012. The prevalence of diabetes mellitus has increased in recent decades, the nocturnal lifestyle and advancing age are directly involved in this mechanism, influencing the production of melatonin by the pineal gland, an important circadian synchronizer. Insulin and exercise are the most physiologically relevant stimulators of glucose transport in skeletal muscle. It has been reported in the literature that the pinealectomized animal shows insulin resistance and reduced synthesis of GLUT4. Furthermore, in exercise situations, these animals are incapable of showing the typical metabolic adaptations of adipose tissue and skeletal muscle. Our results showed that in skeletal muscle (soleus) there was an increase in the rate of glucose oxidation and glycogen synthesis in all groups trained. However, the diabetic showed a reduction in glucose oxidation and in glycogen synthesis, but this deficit was correct by supplementation with melatonin. Our data are consistent with the literature, showing that diabetes mellitus affect the sensitivity of skeletal muscle insulin action, reducing glucose uptake and glycogen synthesis. Nevertheless, this event is corrected by daily supplementation with melatonin, which seems to improve the phosphorylation of insulin receptor substrate (IRS-1 e 2), and the activity of phosphoinositide 3-kinase (PI3-K). Physical training increased GLUT4 expression, and improved insulin signaling pathway, increasing the total expression of IRS-1 protein in the control group trained. Until the present time, the combination of these therapies have shown a positive effect on metabolism and contributed to an effective improvement in quality of life of these animals. Key-words: Melatonin. Physical training. Diabetes. Energy metabolism. LISTA DE ILUSTRAÇÕES Figura 1 Localização anatômica da glândula pineal de rato localizada na região epitalâmica.........................................................................14 Figura 2 Via bioquímica com os indóis precursores e o ponto de atuação de cada enzima na biossíntese de melatonina............................... 15 Figura 3 Via de sinalização da síntese de melatonina em roedores.............................................................................................................. 16 Figura 4 Representação esquemática da informação fotoperiódica transmitida pela síntese de melatonina......................................... 17 Figura 5 Incidência mundial de diabetes mellitus tipo II.................................. 22 Figura 6 Estrutura molecular da AMPK........................................................... 29 Figura 7 – Avaliação do protocolo de treinamento..............................................45 Figura 8 – Avaliação do peso corporal................................................................47 Figura 9 – Avaliação do conteúdo de melatonina...............................................49 Figura 10 – Avaliação da glicemia e insulinemia................................................50 Figura 11 – Avaliação da captação de glicose....................................................51 Figura 12 – Avaliação da síntese de glicogênio muscular..................................53 Figura 13 – Avaliação do conteúdo de glicogênio muscular e hepático...........................................................................................................55 Figura 14 Avaliação do conteúdo total da proteína glut 4 no músculo sóleo................................................................................................57 Figura 15 – Avaliação do conteúdo total da proteína AMPK no músculo sóleo................................................................................................58 Figura 16 – Avaliação do conteúdo total da proteína IRS-1 no músculo sóleo................................................................................................59 |
| File Format | PDF HTM / HTML |
| DOI | 10.11606/T.42.2012.tde-13112012-091022 |
| Alternate Webpage(s) | https://teses.usp.br/teses/disponiveis/42/42137/tde-13112012-091022/publico/RonaldoMeiraMelo_Doutorado.pdf |
| Alternate Webpage(s) | https://doi.org/10.11606/T.42.2012.tde-13112012-091022 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
