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The crystal structure and absolute configuration of fusidic acid methyl ester 3-p-bromobenzoate
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cooper, Alan Hodgkin, Dorothy Mary Crowfoot |
| Copyright Year | 1968 |
| Abstract | Abstract The crystal and molecular structure of the steroid antibiotic, fusidic acid, has been determine by X-ray diffraction methods. The structure was solved from the 3-dimensional Patterson and Fourier syntheses and was refined by block-diagonal least-squares to a final R factor of 0·15. The steroid skeleton contains the unusual configurations 3α-OH, 4α-CH 3 , 5α-H, 8α·CH 3 , 9β-H, 10β-CH 3 , 11α-OH, 13α-H, 14β-CH 3 , 16β-OCOCH 3 and all ring junctions are trans fused with rings A and C syn to ring B. Rings A and C have chair conformations while ring B is a flattened boat. Comparison with other boat-shaped cyclohexane rings leads to the proposal that cyclohexane rings of this conformation may normally be flattened unless constrained to take up the more regular conformation usually assigned. |
| Starting Page | 909 |
| Ending Page | 922 |
| Page Count | 14 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0040-4020(68)88041-X |
| Alternate Webpage(s) | https://pillbuys.com/research/Fusidic%20acid/8.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/0040-4020%2868%2988041-X |
| Volume Number | 24 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
