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[Acute interstitial pneumonia in patient with rheumatoid arthritis treated with leflunomide].
| Content Provider | Semantic Scholar |
|---|---|
| Author | Siemion-Szcześniak, Izabela Bartoszuk, Iwona Bartosiewicz, Małgorzata Jakubowska, Lilia Wesołowski, Stefan Kus, Jolanta |
| Copyright Year | 2014 |
| Abstract | Leflunomide (LEF) is an isoxazole derivative used as disease-modifying anti-rheumatic drug (DMARD) in the treatment of rheumatoid arthritis (RA). It is effective and safe in patients with active RA, in whom standard treatment is insufficient or contraindicated, but it can cause interstitial lung disease (ILD). Identified risk factors for LEF-induced ILD include pre-existing ILD, cigarette smoking, low body weight, and use of loading dose. LEF should be avoided in patients with pre-existing ILD. We present a case of 59-year-old male with RA and a history of smoking and methotrexate (MTX) treatment, who developed dyspnoea, non-productive cough, and fever about two months after the administration of LEF. The clinical and radiological presentation was of acute pneumonia. The patient was treated with methylprednisolone pulse, prednisone, and cyclophosphamide, but he died of respiratory failure. |
| Starting Page | 346 |
| Ending Page | 355 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://journals.viamedica.pl/advances_in_respiratory_medicine/article/download/PiAP.2014.0075/27640 |
| PubMed reference number | 25339568v1 |
| Alternate Webpage(s) | https://doi.org/10.5603/PiAP.2014.0075 |
| DOI | 10.5603/PiAP.2014.0075 |
| Journal | Pneumonologia i alergologia polska |
| Volume Number | 82 |
| Issue Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antirheumatic Drugs, Disease-Modifying Cessation of life Cigarette smoking behavior Coughing Cyclophosphamide Dyspnea Fever Isoxazoles Leukemia, Myelocytic, Acute Lung Diseases, Interstitial Lung diseases Methotrexate Methylprednisolone Patients Pneumonia, Interstitial Prednisone Respiratory Insufficiency Rheumatoid Arthritis acute pneumonia leflunomide productive cough |
| Content Type | Text |
| Resource Type | Article |
