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SIB 1893, a selective mGluR5 receptor antagonist, potentiates the anticonvulsant activity of oxcarbazepine against amygdala-kindled convulsions in rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Borowicz, Kinga K. Łuszczki, Jarogniew J. Czuczwar, Stanisław J. |
| Copyright Year | 2004 |
| Abstract | SIB 1893 (a non-competitive antagonist of group I metabotropic glutamate receptors), given at 40 mg/kg (but not at 20-30 mg/kg), shortened the afterdischarge duration in amygdala-kindled rats, being ineffective on other seizure parameters - seizure severity, seizure duration, and afterdischarge threshold. Oxcarbazepine (at 7.5 mg/kg, but not at 5 mg/kg), a newer antiepileptic drug, reduced seizure severity, seizure and afterdischarge durations. When combined at ineffective doses in amygdala kindling, SIB 1893 at 20 or 30 mg/kg and oxcarbazepine at 5 mg/kg, significantly reduced seizure and afterdischarge durations. The results indicate that combinations of oxcarbazepine with antagonists of group I metabotropic glutamate receptors may offer a novel therapeutic approach in cases of drug-resistant epilepsy. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 15520501 |
| Journal | Medline |
| Volume Number | 56 |
| Issue Number | 4 |
| Alternate Webpage(s) | http://if-pan.krakow.pl/pjp/pdf/2004/4_459_ab.pdf |
| Alternate Webpage(s) | http://www.if-pan.krakow.pl/pjp/pdf/2004/4_459.pdf |
| Alternate Webpage(s) | http://rabbit.if-pan.krakow.pl/pjp/pdf/2004/4_459_ab.pdf |
| Alternate Webpage(s) | http://www.if-pan.krakow.pl/pjp/pdf/2004/4_459_ab.pdf |
| Alternate Webpage(s) | http://rabbit.if-pan.krakow.pl/pjp/pdf/2004/4_459.pdf |
| Alternate Webpage(s) | http://if-pan.krakow.pl/pjp/pdf/2004/4_459.pdf |
| Journal | Polish journal of pharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
