NDLI: Solvent Effects on Tautomeric and Microscopic Protonation Constants of Glycine in Different Aqueous Solutions of 1, 4-dioxane

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Solvent Effects on Tautomeric and Microscopic Protonation Constants of Glycine in Different Aqueous Solutions of 1, 4-dioxane

Content Provider	Semantic Scholar
Author	Mojarrad Shamel, Ali Gharib,, Farrokh
Copyright Year	2012
Abstract	The acid-base equilibria of glycine have been studied in different aqueous solutions of 1,4-dioxane (0-50 % by v/v) using potentiometric method. In this study, the macro and micro protonation constants of the amino acid and its tautomeric constant have been determined at 25 °C and constant ionic strength 0.1 mol dm -3 (NaCl). The protonation and the tautomeric constants of glycine in different binary mixtures were analyzed in terms of Kamlet, Abboud and Taft (KAT) parameters. Single-parameter correlations of the constants versus α (hydrogen-bond donor acidity), β (hydrogenbond acceptor basicity) and π* (dipolarity/polarizability) are poor in all solutions. Multi-parameter correlations show better results, but dual-parameter correlations represent significant improvements with regard to the single- and multi-parameter models. Linear correlation is observed when the experimental protonation constant values are plotted versus the calculated ones, while the KAT parameters are considered. Finally, the results are discussed in terms of the effect of the solvent on protonation and tautomeric constants.
Starting Page	41
Ending Page	50
Page Count	10
File Format	PDF HTM / HTML
Volume Number	9
Alternate Webpage(s)	http://jptc.srbiau.ac.ir/pdf_6719_6d88dcd255880d814b8ebef98795169e.html
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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