Znaczenie uropatogennych szczepów Escherichia coli (UPEC) w etiopatogenezie zakażeń układu moczowego

Content Provider	Semantic Scholar
Author	Chmielewska, Sylwia Joanna Fiedoruk, Krzysztof Daniluk, Tamara Sciepuk, Malgorzata Kaczmarzyk, Danuta Leszczynska, Katarzyna
Copyright Year	2016
Abstract	Urinary tract infections (UTIs) are one of the most widespread infections, particularly among women (40–50%) as well as newborns, infants and elderly persons. In addition, recurrent episodes of UTIs are common and frequently become chronic. Escherichia coli is the most common cause of UTIs, bothcommunityand hospital-acquired, followed by other Enterobacteriaceae (Proteus spp., Klebsiella spp.), Pseudomonas spp. and Gram-positive cocci. The majority of UTIs are caused by uropathogenic E. coli (UPEC) characterized by the presence of various adhesive fimbriae (pili) e.g., type 1 or P, S and Afa/Dr fimbriae, the crucial virulence factors for their pathogenic capabilities. For example, type 1 fimbriae are common among cystitis-associated UPEC, P fimbriae are characteristic adhesins in E. coli pyelonephritis, and Dr fimbriae UPEC strains are frequently isolated (40%) from pregnancy-associated pyelonephritis cases. In consequence, Dr+ E. coli may contribute to serious pregnancy complications, including premature births or damage of the fetus. Therefore, the more extensive knowledge about mechanisms of pathogenesis of UPEC strains may facilitate development of novel diagnostic methods and might prove essential for better risk assessment for patients with UTIs.
File Format	PDF HTM / HTML
Volume Number	55
Alternate Webpage(s)	http://www.pm.microbiology.pl/web/archiwum/vol5512016045.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article