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Isolation and Structural Investigations on (2S,3S ) and (2S,3R)- Tetrahydro -3-Hydroxy-5- Oxo-2,3-Furandicarboxylicacids
| Content Provider | Semantic Scholar |
|---|---|
| Copyright Year | 2014 |
| Abstract | III.01 Chiral -butyrolactone and related molecules Optically active -butyrolactones and related bislactones with various ring appendages are ubiquitous in nature and have attracted much attention in recent years due to their broad applications in biologically active natural products. Optically pure γbutyrolactones have often been played a key role as building blocks in the syntheses of many types of natural products including antibiotics, pheromones, antifungal and flavour components. Chiral -butyrolactones functionalized at the ring C atoms are found to be the core unit of several classes of marketed and potential therapeutic drugs. These classes span anti-inflammatory phospholipase A2 inhibitors (Cinatrin class), antineoplastic agents (PKC inhibitors), antihypertensive agents (vasodilators class), antiarthritic agents, ATP citrate lyase inhibitor, antibacterial and antifungal reagents. In addition, it is also recognized as a cognition-disorders agent (TableIII.01). Table-III.01 Chiral molecules of potent biological applications |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://shodhganga.inflibnet.ac.in:8080/jspui/bitstream/10603/25743/12/12_chapter%203.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
