Intracerebral microinjections of Δ9-tetrahydrocannabinol: search for the impairment of spatial memory in the eight-arm radial maze in rats

Content Provider	Semantic Scholar
Author	Egashira, Nobuaki Mishima, Kenichi Iwasaki, Katsunori Fujiwara, Michihiro
Copyright Year	2002
Abstract	The purpose of this study was to identify brain sites that contribute to the delta(9)-tetrahydrocannabinol (delta(9)-THC)-induced impairment of spatial memory in rats. Rats were tested in the eight-arm radial maze after microinjections of delta(9)-THC into one of 14 different brain regions. The bilateral microinjection of delta(9)-THC (20 microg/side) impaired spatial memory when injected into the dorsal hippocampus (DH), ventral hippocampus (VH) or dorsomedial thalamus nucleus (DMT). However, rats treated with delta(9)-THC into DMT produced preseverative behavior which has not been observed by systemic administration of delta(9)-THC. On the other hand, spatial memory was unaffected by microinjections of delta(9)-THC into the other 11 areas examined: frontal (FC) and frontoparietal (FPC) cortex, central (ACE) and basolateral (ABL) amygdaloid nucleus, medial caudate putamen (CPM), lateral hypothalamus (LH), mammillary body (MB), basal forebrain (BF), medial septal nucleus (SEP) and dorsal (DR) and median (MR) raphe nucleus. These results suggest that DH and VH may be important brain sites for the delta(9)-THC-induced impairment of spatial memory.
Starting Page	239
Ending Page	245
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/S0006-8993(02)03247-X
PubMed reference number	12376185
Journal	Medline
Volume Number	952
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S000689930203247X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S000689930203247X?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0006-8993%2802%2903247-X
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article