Avaliação da toxicidade e da degradação do fármaco cloridrato de fluoxetina, em solução aquosa e em mistura com esgoto doméstico, empregando irradiação com feixe de elétrons

Content Provider	Semantic Scholar
Author	Silva, Vanessa Honda Ogihara
Copyright Year	2014
Abstract	Extensive use of drugs, lack of management in the production and disposal of these products as well as the difficulty in removing residues of pharmaceuticals during wastewater treatment phases imply the release of these micropollutants in water resources. Fluoxetine hydrochloride, known commercially as Prozac ® , have been often used in many countries. Studies demonstrate their presence in the environment and potential damage that this drug may cause the biota. Therefore, this paper studied a treatment technology (AOP Advanced Oxidative Process) using ionizing radiation from an electron accelerator, for the degradation of the drug fluoxetine hydrochloride in aqueous solution and mixed with domestic sewage. After irradiation at aqueous solution chemical analyzes at the drug were done using spectrophotometry UV/VIS, Ultra Fast Liquid Chromatography (detectors UV/ VIS and fluorescence) and quantification of Total Organic Carbon (TOC). Acute toxicity tests (Daphnia similis and Vibrio fischeri) and chronic (Ceriodaphnia dubia) were employed. The efficiency for the degradation of the drug was greater than 98.00% at the lowest absorbed dose of radiation (0.5 kGy), however there was low rate of mineralization to the doses applied in this study. The efficiency reduction of toxicity was 83.75% using Daphnia similis at 0.5 kGy of absorbed dose and 87.24% at 5.0 kGy to fluoxetine hydrochloride, efficiency was 100.00% in reducing toxicity to domestic sewage and the mixture (CF + sewage) was 79.32% at a dose of 5.0 kGy. The efficiency to Vibrio fischeri was 17.26% (better efficiency at the dose of 5.0 kGy) and after correction of pH to a better performance was 20.0 kGy (26.78%), for sewage and mixture efficiencies were about 20,00% for all doses of radiation applied. In relation to chronic toxicity effects to Ceriodaphnia dubia efficiency was 97.50% at 5.0 kGy. It was verified that Ceriodaphnia dubia is more sensitive to the drug, followed by the bacterium Vibrio fischeri and finally Daphnia similis. Key words: fluoxetine hydrochloride degradation, ionizing radiation, mixture toxicity
File Format	PDF HTM / HTML
DOI	10.11606/D.85.2014.tde-22042014-155700
Alternate Webpage(s)	https://teses.usp.br/teses/disponiveis/85/85131/tde-22042014-155700/publico/2014SilvaAvaliacao.pdf
Alternate Webpage(s)	http://pelicano.ipen.br/PosG30/TextoCompleto/Vanessa%20Honda%20Ogihara%20Silva_M.pdf
Alternate Webpage(s)	https://doi.org/10.11606/D.85.2014.tde-22042014-155700
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article