Loading...
Please wait, while we are loading the content...
Similar Documents
What does the Allen Gene Expression Atlas tell us about mouse brain evolution
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mukhopadhyay, Swagatam Grange, Pascal Sengupta, Anirvan M. Mitra, Partha P. |
| Copyright Year | 2012 |
| Abstract | We use the Allen Gene Expression Atlas (AGEA) and the OMA ortholog dataset to investigate the evolution of mouse-brain neuroanatomy from the standpoint of the molecular evolution of brain-specific genes. For each such gene, using the phylogenetic tree for all fully sequenced species and the presence of orthologs of the gene in these species, we construct and assign a discrete measure of evolutionary age. The gene expression profile of all gene of similar age, relative to the average gene expression profile, distinguish regions of the brain that are over-represented in the corresponding evolutionary timescale. We argue that the conclusions one can draw on evolution of twelve major brain regions from such a molecular level analysis supplements existing knowledge of mouse brain evolution and introduces new quantitative tools, especially for comparative studies, when AGEA-like data sets for other species become available. Using the functional role of the genes representational of a certain evolutionary timescale and brain region we compare and contrast, wherever possible, our observations with existing knowledge in evolutionary neuroanatomy. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://arxiv.org/pdf/1206.0324v1.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
