NDLI: System for Measuring Drop Volume and Consistency in Lab-on-Chip Applications

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System for Measuring Drop Volume and Consistency in Lab-on-Chip Applications

Content Provider	Semantic Scholar
Author	Kipman, Yair Mehta, Pavan
Copyright Year	2011
Abstract	Droplet visualization is a common practice during labon-chip development and process verification. Developers typically use high-speed cameras and microscope optics to capture images of droplets in-channel, which are then assessed visually or with manual measurement methods. However, there is an increasing need for accurate droplet characterization such as volume consistency, and, as such, a more sophisticated system for image capture and analysis has been required. A machine vision based system has been developed for measuring in-channel characteristics of droplets for lab-onchip microfluidic applications. The small, fully integrated system can be used in R&D and in production and combines a high-powered LED strobe and strobe control electronics, a digital camera, and specialized optics. ImageXpert software provides a flexible platform for automatically analyzing the volume of individual droplets, and for assessing droplet consistency by collecting and reporting the statistics of the droplet population in-channel (the available instantaneous population being defined by flow rate, droplet size and camera field of view), or populations of droplets over time. The high-powered strobe allows for very short pulse widths (exposure times), which decreases image blur due to droplet motion compared to high speed camera systems, and increases measurement accuracy. Using the newly developed system, droplets of varying size can be measured including droplets down to 1 picoliter in volume, depending on the needs of the application. This paper will give an overview of the ImageXpert system, and will include examples for measurement of inchannel droplet volume for lab-on-chip microfluidic applications.
Starting Page	520
Ending Page	523
Page Count	4
File Format	PDF HTM / HTML
Volume Number	2
Alternate Webpage(s)	https://briefs.techconnect.org/wp-content/volumes/Nanotech2011v2/pdf/1350.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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