NDLI: Bactericidal activity of ethanolic extracts of propolis against Staphylococcus aureus isolated from mastitic cows

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Bactericidal activity of ethanolic extracts of propolis against Staphylococcus aureus isolated from mastitic cows

Content Provider	Semantic Scholar
Author	Santana, Henrique Freitas Barbosa, Ana Andréa Teixeira Ferreira, Sukarno Olavo Mantovani, Hilário Cuquetto
Copyright Year	2012
Abstract	Staphylococcus aureus is an important pathogen for both humans and animals, and it has been an ubiquitous etiological agent of bovine mastitis in dairy farms worldwide. Elimination of S. aureus with classic antibiotics is difficult, and the current study aimed to evaluate the efficacy of ethanolic extracts of propolis (EEP) against S. aureus cultivated in complex media or milk. EEP (0–0.5 mg ml−1) decreased growth of S. aureus in BHI media and 1 mg ml−1 was bactericidal against washed cell suspensions (107 CFU ml−1). Propolis extracts also killed S. aureus cells resuspended in milk, but the bactericidal dose was at least 20-fold greater. Cultures that were transferred for at least 60 generations with sub-lethal doses of propolis did not change much their sensibility to EEP. Atomic force microscopy images revealed changes in morphology and cell size of S. aureus cells exposed to EEP (0.5 mg ml−1). Our results indicate that propolis extracts might be effective against mastitis-causing S. aureus strains in vivo, but milk constituents affect the inhibitory activity of propolis. Considering that propolis-resistance appears to be a phenotype not easily selected, the use of EEP combined or not with other antimicrobial agents might be useful for mastitis control in vivo.
Starting Page	485
Ending Page	491
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1007/s11274-011-0839-7
PubMed reference number	22806843
Journal	Medline
Volume Number	28
Alternate Webpage(s)	https://www.sigaa.ufs.br/sigaa/verProducao?idProducao=52066&key=7419b4ce4124ea57491c41646cd260f3
Alternate Webpage(s)	https://doi.org/10.1007/s11274-011-0839-7
Journal	World journal of microbiology & biotechnology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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