NDLI: Amphiphilic trismethylpyridylporphyrin-fullerene (C70) dyad: an efficient photosensitizer under hypoxia conditions.

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Amphiphilic trismethylpyridylporphyrin-fullerene (C70) dyad: an efficient photosensitizer under hypoxia conditions.

Content Provider	Semantic Scholar
Author	Guan, Mirong Qin, Tingxiao Ge, Jiechao Zhen, Mingming Xu, Wei Zheng Chen, Daiqin Li, Shumu Wang, Chunru Su, Hongmei Shu, Chunying
Copyright Year	2015
Abstract	Amphiphilic trismethylpyridylporphyrin-C70 (PC70) dyad with improved photosensitization has been successfully prepared. The PC70 dyad forms a liposomal nanostructure through molecular self-assembling. An increased absorption coefficient in the visible region, good biocompatibility, and high photostability were observed on the self-assembling structure. Surprisingly, in comparison with previously reported photosensitizer porphyrins, PC70 exhibited an enhanced photodynamic therapy (PDT) effect under hypoxia conditions. Further investigations illustrated that PC70 went through an extremely long-life triplet state (211.3 μs) under hypoxia, which enabled the exiguous oxygen to approach and interact with the activated (3P-C70)* more efficiently and produce more singlet oxygen. This would overcome the problem of existing photosensitizers of low PDT efficiency in cancerous tissues under hypoxia. The excellent properties of PC70 dyad make it a promising phototherapeutic agent, especially for the treatment of early- and late-stage cancers under shallow and hypoxia tissues.
Starting Page	776
Ending Page	783
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1039/C4TB01314J
PubMed reference number	32262168
Journal	Medline
Volume Number	3
Issue Number	5
Alternate Webpage(s)	http://www.rsc.org/suppdata/tb/c4/c4tb01314j/c4tb01314j1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C4TB01314J
Journal	Journal of materials chemistry. B
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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