Estudo da atividade enzimatica e das propriedades fisico-quimicas do organo-gel atraves de reações catalisadas pela CV lipase

Content Provider	Semantic Scholar
Author	Aguiar, Lucia Maria Z.
Copyright Year	1992
Abstract	This work studies the utilization of the CV lipase enzyme in organic synthesis, immobilized in a microemulsion-based organo-gel of cyclohexane. Initially, a detailed literature review on the application of enzymes in organic synthesis is presented. The main works that investigated this area are discussed with respect to their ideas, hypotheses, experiments and theories which made up the basis of this field of knowledge. The main research focus is the characterization of the microemulsion-based organo-gel as regards its physicochemical properties along with its subsequent use in the CV lipase immobilization. The resulting medium is, thus, used for executing syntheses of esters, thioesters and amides. In the ester syntheses, parameters such as numbers of carbons, branches and insaturation of acid chains were associated with the catalytical efficiency of the CV lipase. The solvent effect was also studied concerning its relation to the efficiency of esterification reactions, aiming to identify the relation between the solvent polarity and the reactional medium optimization. Syntheses of amide and thioester were used for verifying the CV lipase activity concerning the substrates which contain SH and NH2 functional groups. The results of those syntheses were compared with each other and with data obtained from the literature, in order to analyse the efficiency of the CV lipase compared to other enzymes, and the efficiency of the microemulsion-based organo-gel compared to the remaining methodologies prescribed for enzymatic synthesis in organic solvents.
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Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article