NDLI: Postnatal Development of Subcallosal Zone Following Suppression of Programmed Cell Death in Bax-deficient Mice

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Postnatal Development of Subcallosal Zone Following Suppression of Programmed Cell Death in Bax-deficient Mice

Content Provider	Semantic Scholar
Author	Kim, Woon Ryoung Sun, Woong
Copyright Year	2013
Abstract	Neural stem cells are found in adult mammalian brain regions including the subgranular zone (SGZ) of the dentate gyrus (DG) and the subventricular zone (SVZ). In addition to these two regions, other neurogenic regions are often reported in many species. Recently, the subcallosal zone (SCZ) has been identified as a novel neurogenic region where new neuroblasts are spontaneously generated and then, by Bax-dependent apoptosis, eliminated. However, the development of SCZ in the postnatal brain is not yet fully explored. The present study investigated the precise location and amount of neuroblasts in the developing brain. To estimate the importance of programmed cell death (PCD) for SCZ histogenesis, SCZ development in the Bax-knockout (KO) mouse was examined. Interestingly, an accumulation of extra neurons with synaptic fibers in the SCZ of Bax-KO mice was observed. Indeed, Bax-KO mice exhibited enhanced startle response to loud acoustic stimuli and reduced anxiety level. Considering the prevention of PCD in the SCZ leads to sensory-motor gating dysfunction in the Bax-KO mice, active elimination of SCZ neuroblasts may promote optimal brain function.
Starting Page	179
Ending Page	186
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/79/devrepro-17-179.PMC4282302.pdf
PubMed reference number	4282302
Alternate Webpage(s)	https://doi.org/10.12717/DR.2013.17.3.179
DOI	10.12717/dr.2013.17.3.179
Journal	Development & reproduction
Volume Number	17
Language	English
Access Restriction	Open
Subject Keyword	ATBI-1 protein, Arabidopsis Anxiety Disorders Apoptosis Basement membrane zone BP180 Ab:ACnc:Pt:Ser:Qn:IA Bax protein Cell Death Excretory function Histogenic Process Knock-out Mammals Mucosa-Associated Lymphoid Tissue Lymphoma Neuroblast Reflex, Startle Stem cells Structure of dentate gyrus Subventricular Zone Tissue fiber
Content Type	Text
Resource Type	Article

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