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Use of highly active antiretroviral therapy is associated with lower prevalence of anal intraepithelial neoplastic lesions and lower prevalence of human papillomavirus in HIV-infected men who have sex with men.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Snoek, Eric Martin Van Der Ende, Marchina Elisabeth Van Der Hollander, Jan Christiaan Den Driessen, Gertjan Neumann, Hendrik Arend Martino Doornum, Gerard J. J. Van |
| Copyright Year | 2012 |
| Abstract | BACKGROUND The incidence of anal intraepithelial neoplasia (AIN) and anal cancer is increased in HIV-positive men who have sex with men (MSM). Persistent high-risk human papillomavirus (HPV) infection is an important etiologic agent. METHODS In this study, a group of 250 HIV-positive MSM was included to determine the prevalence of AIN and to investigate the role of highly active antiretroviral therapy (HAART), high-risk HPV, and other risk factors possibly associated with this prevalence. RESULTS Among patients included, 108 (43.2%) had lesions suspicious for AIN. Histologic analyses showed AIN 1 in 24 patients (22.2%), AIN 2 in 6 patients (5.6%), and AIN 3 in 10 patients (9.3%). In multivariable analyses, the use of HAART was associated with the absence of AIN (P = 0.045). In MSM without HAART, HPV infection was detected significantly more often compared with those who used HAART (P = 0.010). AIN was associated with HPV types 16 and 6. CONCLUSIONS In this cross-sectional study in 250 HIV-positive MSM, the use of HAART was associated with lower prevalence of AIN and a significantly lower prevalence of HPV. This association between the prevalence of AIN and the absence of HAART may contribute to the current debate on when to start HAART in HIV-infected individuals. |
| Starting Page | 495 |
| Ending Page | 500 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.natap.org/2013/HIV/Use_of_Highly_Active_Antiretroviral_Therapy_Is.1.pdf |
| Alternate Webpage(s) | http://www.natap.org/2012/HIV/UsofHighlyActiveAntiretroviralTherapyIs.1.pdf |
| PubMed reference number | 22695316v1 |
| Alternate Webpage(s) | https://doi.org/10.1097/OLQ.0b013e31825aa764 |
| DOI | 10.1097/OLQ.0b013e31825aa764 |
| Journal | Sexually transmitted diseases |
| Volume Number | 39 |
| Issue Number | 7 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anal carcinoma Antiretroviral Therapy, Highly Active Antiretroviral therapy Anus HIV Infections Human Papillomavirus Intraepithelial Neoplasia Neoplasms Patients anal dysplasia |
| Content Type | Text |
| Resource Type | Article |
