Morning and evening TSH response to TRH and sleep EEG disturbances in major depressive disorder

Content Provider	Semantic Scholar
Author	Staner, Luc Duval, Fabrice Calvi-Gries, Françoise Macher, Jean-Paul
Copyright Year	2001
Abstract	1. The aim of this study was to investigate hypothalamo-pituitary-thyroid axis (HPTA) functioning and sleep EEG disturbances in major depressive disorder. 2. Thyroid function was evaluated by determination of TSH levels before and after 8 AM and 11 PM TRH administration on the same day in a sample of 113 consecutively-admitted DSM-IV major depressed inpatients (72 females aged 44.3 +/- 13.0 and 41 males aged 45.7 +/- 10.7) that underwent sleep EEG recordings. 3. A blunted TSH response occurred in 15.9% for 8 AM deltaTSH (maximum increment above baseline at the 8 AM TRH challenge), in 39.8% for 11 PM deltaTSH and in 77% for deltadeltaTSH (difference between 11 PM deltaTSH and 8 AM deltaTSH). A negative correlation between deltadeltaTSH and duration of awakenings after sleep onset, and a shorter sleep onset latency in patients with a blunted 11 PM deltaTSH were found, but these two significant relationships disappeared after controlling for the effects of gender and age. 4. The present findings do not support the hypothesis that, in major depression, HPTA dysfunctioning, as reflected in TSH response to TRH, may be related to sleep EEG disturbances.
Starting Page	534
Ending Page	547
Page Count	14
File Format	PDF HTM / HTML
DOI	10.1016/S0278-5846(00)00185-8
PubMed reference number	11370996
Journal	Medline
Volume Number	25
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0278584600001858
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0278584600001858?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0278-5846%2800%2900185-8
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article