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Serum neuron-specific enolase levels are upregulated in patients with acute lymphoblastic leukemia and are predictive of prognosis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liu, Cheng-Cheng Wang, Hailong Wang, Jing-Hua Wang, Liang Toon Geng, Qi-rong Chen, Xiao-qin Lu, Yue |
| Copyright Year | 2016 |
| Abstract | We explored the relationship between neuron-specific enolase (NSE) levels and the clinical features of acute lymphoblastic leukemia (ALL). Seventy ALL patients and forty-two healthy controls were enrolled in this study, and their serum NSE levels were measured using an electrochemiluminescence assay. The serum NSE concentration was higher in ALL patients than in healthy controls. In ALL patients, the mean serum NSE level declined after complete remission (CR) but increased with relapse. In addition, the mean serum NSE level was lower in the CR group than in the non-CR group. High NSE levels were associated with poorer progression-free and overall survival than low NSE levels. Serum NSE levels closely correlated with several clinical features, including the immunophenotype, risk stratification and serum lactate dehydrogenase levels. Multivariate analysis revealed that high NSE expression was an independent prognostic factor in adult ALL patients. NSE mRNA levels were also higher in ALL cell lines and bone marrow mononuclear cells from ALL patients than in control cells. These results suggested that NSE could be a clinical prognostic factor and a potential therapeutic target in ALL. |
| Starting Page | 55181 |
| Ending Page | 55190 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=10473&path%5B%5D=42916 |
| PubMed reference number | 27409171v1 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.10473 |
| DOI | 10.18632/oncotarget.10473 |
| Journal | Oncotarget |
| Volume Number | 7 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bone Marrow Cultured Cell Line ENOLASE Electrochemiluminescence Gamma-Enolase Immunophenotyping Lactate Dehydrogenase Lactic acid Neurons Overall Survival Patients Precursor Cell Lymphoblastic Leukemia Lymphoma Prognostic Factors Stratification childhood acute lymphoblastic leukemia in remission lymphoblast serum ldh |
| Content Type | Text |
| Resource Type | Article |
