NDLI: Altérations synaptiques à la jonction neuromusculaire dans un modèle murin de sclérose latérale amyotrophique

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Altérations synaptiques à la jonction neuromusculaire dans un modèle murin de sclérose latérale amyotrophique

Content Provider	Semantic Scholar
Author	Tremblay, Elsa
Copyright Year	2016
Abstract	..................................................................................................................................... iii Table des matières ....................................................................................................................... v Liste des figures ......................................................................................................................... ix Liste des sigles ........................................................................................................................... xi Liste des abréviations ................................................................................................................ xii Remerciements ......................................................................................................................... xiv Chapitre 1 : Introduction générale ......................................................................................... 1 Préambule ................................................................................................................................... 2 1.1 Sclérose latérale amyotrophique ........................................................................................... 2 1.1.1 Description ..................................................................................................................... 2 1.1.2 Symptomatologie ........................................................................................................... 3 1.1.2.1 Forme bulbaire ........................................................................................................ 3 1.1.2.2 Forme spinale .......................................................................................................... 4 1.1.3 Diagnostic ...................................................................................................................... 4 1.1.4 Étiologie ........................................................................................................................ .6 1.1.4.1 Facteurs environnementaux .................................................................................... 6 1.1.4.2 Mutations génétiques .............................................................................................. 7 1.2 Protéine Superoxyde dismutase SOD1 ................................................................................. 9 1.2.1 Fonctions et propriétés de l'enzyme ............................................................................... 9 1.2.2 Toxicité SOD1 dans la sclérose latérale amyotrophique ............................................. 10 1.2.2.1 Modèles animaux SOD1 ....................................................................................... 11 1.2.2.2 Activité enzymatique ............................................................................................ 12
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://papyrus.bib.umontreal.ca/xmlui/bitstream/handle/1866/13655/Tremblay_Elsa_2015_memoire.pdf?isAllowed=y&sequence=2
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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