Structural analysis of the basal ganglia in schizophrenia

Content Provider	Semantic Scholar
Author	Mamah, Daniel Wang, Lei Barch, Deanna M. Erausquin, Gabriel Alejandro De Csernansky, John G.
Copyright Year	2007
Abstract	Increases in the total volume of basal ganglia structures have been reported in schizophrenia. However, patterns of basal ganglia shape change, which can reveal localized changes in substructure volumes, have not been investigated. In this study, the total volume and shape of several basal ganglia structures were compared in subjects with and without schizophrenia. T(1)-weighted magnetic resonance scans were collected in 54 schizophrenia and 70 comparison subjects. High-dimensional (large-deformation) brain mapping was used to assess the shape and volume of several basal ganglia structures. The relationships of shape and volume measures with psychopathology, cognition and motor function were also assessed. Left and right volumes of the caudate and putamen, as well as the right globus pallidus volume, were significantly increased in subjects with schizophrenia as compared to comparison subjects after total brain volume was included as a covariate. Significant differences in shape accompanied these volume changes in the caudate, putamen and globus pallidus, after their total volumes were included as covariates. There were few significant correlations between volume or shape measures and either cognitive function or clinical symptoms, other than a positive correlation between an attention/vigilance cognitive dimension and the volume of the caudate and putamen, and a negative correlation between nucleus accumbens volume and delusions. In conclusion, basal ganglia volumes relative to total brain volume were larger in schizophrenia subjects than healthy comparison subjects. Specific patterns of shape change accompanied these volume differences.
Starting Page	59
Ending Page	71
Page Count	13
File Format	PDF HTM / HTML
DOI	10.1016/j.schres.2006.08.031
PubMed reference number	17071057
Journal	Medline
Volume Number	89
Alternate Webpage(s)	http://ccpweb.wustl.edu/pdfs/Mamah2007.pdf
Alternate Webpage(s)	http://ccpweb.wustl.edu/pdfs/SABarch2006.pdf
Alternate Webpage(s)	http://conte.wustl.edu/PDFs/9.pdf
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0920996406003860?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	http://www.conte.wustl.edu/PDFs/9.pdf
Alternate Webpage(s)	http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1839817&blobtype=pdf
Alternate Webpage(s)	http://iac.wustl.edu/~ccpweb/pdfs/Mamah2007.pdf
Alternate Webpage(s)	http://iac.wustl.edu/~ccpweb/pdfs/SABarch2006.pdf
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0920996406003860
Alternate Webpage(s)	https://doi.org/10.1016/j.schres.2006.08.031
Journal	Schizophrenia Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article