NDLI: Meta-Analysis of the Relationship between Multiple Sclerosis and Migraine

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Meta-Analysis of the Relationship between Multiple Sclerosis and Migraine

Content Provider	Semantic Scholar
Author	Pakpoor, Julia Handel, Adam E. Giovannoni, Gavin Dobson, Ruth Sreeram V. Ramagopalan
Copyright Year	2012
Abstract	BACKGROUND Studies investigating a proposed association between multiple sclerosis (MS) and migraine have produced conflicting results and a great range in the prevalence rate of migraine in MS patients. By meta-analysing all available data we aimed to establish an overall estimate of any association in order to more accurately inform clinicians and care-givers about a potential association between MS and migraine. METHODS Pubmed and EMBASE were searched to identify suitable studies. Studies were included if they were a case-control study or cohort study in which controls were not reported to have another neurological condition, were available in English, and specified migraine as a headache sub-type. The odds ratio (OR) of migraine in MS patients vs. controls was calculated using the inverse variance with random effects model in Review Manager 5.1. RESULTS Eight studies were selected for inclusion, yielding a total of 1864 MS patients and 261563 control subjects. We found a significant association between migraine and MS (OR = 2.60, 95% CI 1.12-6.04), although there was significant heterogeneity. Sensitivity analysis showed that migraine without aura was associated with MS OR = 2.29 (95% CI 1.14-4.58), with no significant heterogeneity. CONCLUSIONS MS patients are more than twice as likely to report migraine as controls. Care providers should be alerted to ask MS patients about migraine in order to treat it and potentially improve quality of life. Future work should further investigate the temporal relationship of this association and relationship to the clinical characteristics of MS.
File Format	PDF HTM / HTML
DOI	10.1371/journal.pone.0045295
PubMed reference number	23024814
Journal	Medline
Volume Number	7
Alternate Webpage(s)	https://qmro.qmul.ac.uk/xmlui/bitstream/handle/123456789/5223/RAMAGOPALANMeta-Analysis2012FINAL.pdf;sequence=2
Alternate Webpage(s)	https://doi.org/10.1371/journal.pone.0045295
Journal	PloS one
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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