NDLI: Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7cc05159j

Content Provider	Semantic Scholar
Author	Kumar, Pawan El-Sagheer, Afaf Helmy Truong, Lynda Brown, Tom
Copyright Year	2017
Abstract	Oligonucleotides containing internal triazole-3'-LNA linkages bind to complementary RNA with similar affinity and specificity to unmodified oligonucleotides, and significantly better than oligonucleotides containing triazole alone. In contrast LNA on the 5'-side of the triazole does not stabilise duplexes. Triazole-LNA confers great resistance towards enzymatic degradation relative to LNA alone.
Starting Page	8910
Ending Page	8913
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1039/c7cc05159j
PubMed reference number	28748236
Journal	Medline
Volume Number	53
Alternate Webpage(s)	http://www.rsc.org/suppdata/c7/cc/c7cc05159j/c7cc05159j1.pdf
Alternate Webpage(s)	https://pubs.rsc.org/en/content/articlepdf/2017/cc/c7cc05159j
Alternate Webpage(s)	https://doi.org/10.1039/c7cc05159j
Journal	Chemical communications
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7cc05159j