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Synthesis of ‘Reversed' Pyrimidine and Pyrazolo[1,5-a]pyrimidine-C-Nucleoside Analogues from Push-Pull Functionalized α-d-xylo-Hept-5-ulofuranurononitrile
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hashmi, Imran Ali Ali, Firdous Imran Feist, Holger Michalik, Manfred Reinke, Helmut Peseke, Klaus |
| Copyright Year | 2007 |
| Abstract | 3- O-Benzyl-6-deoxy-1,2- O-isopropylidene-6-[bis(meth-ylsulfanyl)methylene]-α- D- XYLO-hept-5-ulofuranurononitrile ( 1) was reacted with acetamidinium chloride, S-methylisothiouronium sulfate, and guanidinium chloride, respectively, in the presence of triethylamine to furnish the 2-substituted 4-(3- O-benzyl-1,2- O-isopropylidene-α- D- XYLO-tetrofuranos-4-yl)-6-methylsulfanylpyrimidine-5-carbonitriles 2A- C. Treatment of 1 with different 5-aminopyrazole-4-carboxylic acid derivatives yielded the 8-(3- O-benzyl-1,2- O-isopropylidene-α- D- XYLO-tetrofuranos-4-yl)-6-methylsulfanylpyrazolo[1,5- A]pyrimidine-3,7-dicarboxylic acid derivatives 3A- C. |
| Starting Page | 2819 |
| Ending Page | 2822 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1055/s-2007-983879 |
| Volume Number | 2007 |
| Alternate Webpage(s) | http://www.xiuzhengrd.com/ejournals/pdf/synthesis/doi/10.1055/s-2007-983879.pdf |
| Alternate Webpage(s) | https://doi.org/10.1055/s-2007-983879 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
