NDLI: Endothelium Derived Nitric Oxide Synthase Negatively Regulates the PDGF-Survivin Pathway during Flow-Dependent Vascular Remodeling

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Endothelium Derived Nitric Oxide Synthase Negatively Regulates the PDGF-Survivin Pathway during Flow-Dependent Vascular Remodeling

Content Provider	Semantic Scholar
Author	Zhang, Yuanyuan Zhang, Xinbo Rudic, Radu Daniel Bauer, Philip M. Altieri, Dario C. Sessa, William C.
Copyright Year	2012
Abstract	Chronic alterations in blood flow initiate structural changes in vessel lumen caliber to normalize shear stress. The loss of endothelial derived nitric oxide synthase (eNOS) in mice promotes abnormal flow dependent vascular remodeling, thus uncoupling mechanotransduction from adaptive vascular remodeling. However, the mechanisms of how the loss of eNOS promotes abnormal remodeling are not known. Here we show that abnormal flow-dependent remodeling in eNOS knockout mice (eNOS (-/-)) is associated with activation of the platelet derived growth factor (PDGF) signaling pathway leading to the induction of the inhibitor of apoptosis, survivin. Interfering with PDGF signaling or survivin function corrects the abnormal remodeling seen in eNOS (-/-) mice. Moreover, nitric oxide (NO) negatively regulates PDGF driven survivin expression and cellular proliferation in cultured vascular smooth muscle cells. Collectively, our data suggests that eNOS negatively regulates the PDGF-survivin axis to maintain proportional flow-dependent luminal remodeling and vascular quiescence.
File Format	PDF HTM / HTML
DOI	10.1371/journal.pone.0031495
PubMed reference number	22355372
Journal	Medline
Volume Number	7
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/fe/f4/pone.0031495.PMC3280303.pdf
Alternate Webpage(s)	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031495&type=printable
Alternate Webpage(s)	https://doi.org/10.1371/journal.pone.0031495
Journal	PloS one
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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