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BOLD fMRI of forepaw stimulation at different amplitudes in mice
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bosshard, Simone C. Baltes, Christof Mueggler, Thomas Rudin, Markus |
| Copyright Year | 2008 |
| Abstract | INTRODUCTION: fMRI has become an important tool for studies of the functional anatomy of the rodent brain under normal and pathologic conditions as well as for elucidating the mechanism underlying the BOLD response. However, fMRI studies in mice are sparse. This is due to the small size of the mouse, which is challenging both from a MR technological and from a physiological perspective. Eliciting robust BOLD responses requires highly sensitive RF detector systems (e.g. cryogenic surface coils [1,2]) and maintenance of stable physiological conditions, e.g. constant levels of blood gases. Yet, in view of the numerous genetically engineered strains used in biomedical research the relevance of methods enabling noninvasive phenotyping (including mouse fMRI) will increase. The objective of this study was to analyze the robustness and reproducibility of the BOLD fMRI response to electrical forepaw stimulation as a function of the stimulus amplitude. This stimulation paradigm has been widely used in rats and studies have revealed that noxious-evoked activation patterns corresponded well with the structures known to be part of the pain processing pathway. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cds.ismrm.org/protected/09MProceedings/files/00516.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
