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The Effect of X-rays of 1000 R on Male Germ Cells in the Mouse , with Particular Attention to the Difference in X-ray
| Content Provider | Semantic Scholar |
|---|---|
| Copyright Year | 2007 |
| Abstract | A large number of works on the damage to the mammalian testis by radiation have accumulated since Albers-Schonberg's initial report in 1903. It has generally been accepted that the X-ray sensitivity during spermatogenesis varies with the developmental stages of germ cells, and that the depletion of spermatogonia gives rise to orderly disappearance of cells according to their developmental stages; spermatocytes, spermatids and spermatozoa (Regaud and Blanc 1906; Regaud and Lacassagne 1927; Desjardins 1932; Schinz and Slotopolsky 1925; Hertwig 1938; Schaef er 1939; Heller 1948; Eschenbrenner and Miller 1950, 1954; Fogg and Cowing 1951a, b; Shaver 1953; Oakberg 1955a). In the previous papers (Itagaki 1962, 1966; Ito and Itagaki 1963), it was confirmed that spermatogonia are more sensitive to X-rays than other spermatogenetic cell populations and that the rate of depletion and recovery of spermatogonia is related to the irradiated dosage. Thus both degenerative and regenerative phenomena of male germ cells depend upon their effects on the spermatogonia. One of the important subjects in the field of mammalian radiation cytogenetics is to analyze the mechanism of spermatogonial renewal after X-irradiation. An old papers emphasized a transformation hypothesis of neighbouring cells such as Sertoli cells or seminiferous tubule-wall cells into spermatogonia. However, theories that spermatogonia renew themselves by mitosis have been accepted more commonly. Schaefer (1939) has reported that the few spermatogonia which survive at high doses of radiation are resting type "A" cells. Shaver (1953) has noted high sensitivity to inhibition of mitosis of dust-like spermatogonia, and high resistance to irreparable damage describing that these undamaged cells participate in regeneration. In addition, Oakberg (1955a, b, 1957, 1959) has indicated that type A spermatogonia are of heterogeneous sensitivities depending on mitotic activity and stage of development. It is intention of this paper to study in detail the quantitative change of each spermatogenetic cell population after 1000 R irradiation, and further to understand the |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/ggs1921/45/4/45_4_239/_pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
