NDLI: O Polimorfismo Pro12ala Do Gene Do Receptor Proliferador-ativado De Peroxissomos (ppar) Gama Em Indivíduos Normais Do Sul Do Brasil

Content Provider	Semantic Scholar
Author	Silvello, Daiane Nicoli Simon, Daniel
Copyright Year	2002
Abstract	O receptor prolifetador-ativado de peroxissomos gama (PPAR)-g e o principal regulador daadipogenese e sensibilidade a insulina. Estudos recentes identificaram uma substituicao de prolinapara alanina (Pro12Ala) no PPAR-g. Este polimorfismo foi associado com caracteristicas relacionadasa diabetes e/ou protecao contra a diabetes tipo 2. Este trabalho teve por objetivo o estabelecimentodas metodologias de genotipagem do polimorfismo Pro12Ala e o estudo de sua frequencia emuma amostra de individuos normais caucasoides de Porto Alegre. A frequencia do alelo Pro foi 0,80,e o polimorfismo esta em equilibrio de Hardy-Weinberg. As frequencias obtidas nao diferem dasfrequencias de outros grupos caucasoides anteriormente estudados. Sera realizado um estudo deassociacao para analisar o polimorfismo Pro12Ala e parâmetros clinicos em individuos diabeticos enao-diabeticos .
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.periodicos.ulbra.br/index.php/ic/article/download/1946/1396
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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