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Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ramanujam, Nirmala |
| Copyright Year | 2006 |
| Abstract | A flexible and fast Monte Carlo-based model of diffuse reflectance has been developed for the extraction of the absorption and scattering properties of turbid media, such as human tissues. This method is valid for a wide range of optical properties and is easily adaptable to existing probe geometries, provided a single phantom calibration measurement is made. A condensed Monte Carlo method was used to speed up the forward simulations. This model was validated by use of two sets of liquid-tissue phantoms containing Nigrosin or hemoglobin as absorbers and polystyrene spheres as scatterers. The phantoms had a wide range of absorption (0-20 cm(-1)) and reduced scattering coefficients (7-33 cm(-1)). Mie theory and a spectrophotometer were used to determine the absorption and reduced scattering coefficients of the phantoms. The diffuse reflectance spectra of the phantoms were measured over a wavelength range of 350-850 nm. It was found that optical properties could be extracted from the experimentally measured diffuse reflectance spectra with an average error of 3% or less for phantoms containing hemoglobin and 12% or less for phantoms containing Nigrosin. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://nimmi.bme.duke.edu/sites/nimmi.bme.duke.edu/files/Palmer%20-%20Reflect%20corrected.pdf |
| PubMed reference number | 16512550v1 |
| Volume Number | 45 |
| Issue Number | 5 |
| Journal | Applied optics |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Calibration Chromosome Condensation Extraction Leucaena pulverulenta Monte Carlo Method Phantoms, Imaging Polystyrenes nigrosin spectrophotometer wavelength |
| Content Type | Text |
| Resource Type | Article |
