Loading...
Please wait, while we are loading the content...
Comparison of Pharmacokinetics and Relative Bioavailability of Tablets and Substance of New Dipeptide Neuroleptic Dilept
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shevchenko, Rostislav V. Litvin, Artem A. Kolyvanov, G. B. Zherdev, V. P. Smirnov, Vladimir V. |
| Copyright Year | 2014 |
| Abstract | We studied pharmacokinetics of dilept after single cross-administration of tablets and substance of dilept in a dose of 40 mg to rabbits. The following pharmacokinetic parameters were calculated: maximum plasma concentration of dilept, time to maximum observed concentration, area under the pharmacokinetic curve, elimination half-life, and relative bioavailability. Dilept concentration in blood plasma was estimated using ultra-fast liquid chromatography with mass spectrometry detection. Relative bioavailability of dilept tablets was 93.46±28.91% of that for the substance. |
| Starting Page | 735 |
| Ending Page | 737 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s10517-014-2655-1 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/s10517-014-2655-1 |
| PubMed reference number | 25348562 |
| Alternate Webpage(s) | https://doi.org/10.1007/s10517-014-2655-1 |
| Journal | Medline |
| Volume Number | 157 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
