NDLI: BEL-1, a novel clavulanic acid-inhibited extended-spectrum beta-lactamase, and the class 1 integron In120 in Pseudomonas aeruginosa.

Content Provider	Semantic Scholar
Author	Poirel, Laurent Briñas, Laura Verlinde, Annemie Ide, Louis Nordmann, Patrice L.
Copyright Year	2005
Abstract	Screening by a double-disk synergy test identified a Pseudomonas aeruginosa isolate that produced a clavulanic acid-inhibited expanded-spectrum beta-lactamase (ESBL). Cloning and sequencing identified a novel ESBL, BEL-1, weakly related to other Ambler class A ESBLs. beta-Lactamase BEL-1 hydrolyzed significantly most expanded-spectrum cephalosporins and aztreonam, and its activity was inhibited by clavulanic acid, tazobactam, cefoxitin, moxalactam, and imipenem. This chromosome-encoded ESBL gene was embedded in a class 1 integron containing three other gene cassettes. In addition, this integron was bracketed by Tn1404 transposon sequences at its right end and by P. aeruginosa-specific sequences at its left end.
File Format	PDF HTM / HTML
DOI	10.1128/AAC.49.9.3743-3748.2005
PubMed reference number	16127048
Journal	Medline
Volume Number	49
Issue Number	9
Alternate Webpage(s)	http://www.vlaamsegezondheidszorg.com/sites/default/files/BEL-1.pdf
Alternate Webpage(s)	https://doi.org/10.1128/AAC.49.9.3743-3748.2005
Journal	Antimicrobial agents and chemotherapy
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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