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Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chung, Hyun Jung Park, Tae Gwan |
| Copyright Year | 2007 |
| Abstract | A wide range of polymeric scaffolds have been intensively studied for use as implantable and temporal devices in tissue engineering. Biodegradable and biocompatible scaffolds having a highly open porous structure and good mechanical strength are needed to provide an optimal microenvironment for cell proliferation, migration, and differentiation, and guidance for cellular in-growth from host tissue. A variety of natural and synthetic polymeric scaffolds can be fabricated in the form of a solid foam, nanofibrous matrix, microsphere, or hydrogel. Biodegradable porous scaffolds can be surface engineered to provide an extracellular matrix mimicking environment for better cell adhesion and tissue in-growth. Furthermore, scaffolds can be designed to release bioactive molecules, such as growth factors, DNA, or drugs, in a sustained manner to facilitate tissue regeneration. This paper reviews the current status of surface engineered and drug releasing scaffolds for tissue engineering. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://isites.harvard.edu/fs/docs/icb.topic549116.files/Tissue%20engineering.pdf |
| Alternate Webpage(s) | https://pdfs.semanticscholar.org/371f/27e246cace429679b33bea800540abdea487.pdf |
| PubMed reference number | 17482310v1 |
| Volume Number | 59 |
| Issue Number | 4-5 |
| Journal | Advanced drug delivery reviews |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cell Adhesion Cell Proliferation Extracellular Matrix Hydrogel Implants Microspheres Polymers Review [Publication Type] Tissue Engineering tissue regeneration |
| Content Type | Text |
| Resource Type | Article |
