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Design of dietary polysaccharide and binary monomer mixture of acrylamide and 2-acrylamido-2-methylpropane sulphonic acid based antiviral drug delivery devices
| Content Provider | Semantic Scholar |
|---|---|
| Author | Singh, Baljit Bala, Rajni |
| Copyright Year | 2012 |
| Abstract | Abstract The present article discusses the functionalization of psyllium by binary monomer mixture of acrylamide and 2-acrylamido-2-methylpropane sulphonic acid to develop the new drug delivery devices. These were characterized by SEMs, FTIR, TGA and swelling studies. The swelling kinetics of the hydrogels and release dynamics of drug (indinavir sulphate) from the drug loaded hydrogels has been studied for the evaluation of the swelling and drug release mechanism respectively. The release of the drug from the hydrogels occurred through Fickian diffusion mechanism in pH 2.2 buffer. The antiviral activity of indinavir sulphate for AIDS, anti-diarrhoeal action of psyllium and inhibitory effects of sulphated polymers on STD pathogens will enhance the potential of the drug delivery devices. |
| Starting Page | 346 |
| Ending Page | 358 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.cherd.2011.07.023 |
| Alternate Webpage(s) | https://www.tpbin.com/download-firstpage/25587/article |
| Alternate Webpage(s) | https://doi.org/10.1016/j.cherd.2011.07.023 |
| Volume Number | 90 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
