NDLI: Growth stimulation by coexpression of transforming growth factor-alpha and epidermal growth factor-receptor in normal and adenomatous human colon epithelium.

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Growth stimulation by coexpression of transforming growth factor-alpha and epidermal growth factor-receptor in normal and adenomatous human colon epithelium.

Content Provider	Semantic Scholar
Author	Markowitz, Sanford D. Gerbic, C. Jackson, Jacob Stellato, Tiziana
Copyright Year	1990
Abstract	Autocrine stimulation of the epidermal growth factor receptor (EGF-R), by coexpression of transforming growth factor-alpha (TGF-alpha), causes malignant transformation of some fibroblast cell lines. TGF-alpha and EGF-R are both known to be expressed in colon carcinoma tissue and have been shown coexpressed in colon carcinoma cell lines. TGF-alpha autocrine activation of EGF-R has been suggested as a potential mechanism contributing to abnormal growth control in colon cancer. We now report coexpression of TGF-alpha and EGF-R transcripts in morphologically normal colonic epithelium from five individuals, in colonic adenomas from three individuals, and in a nontumorigenic colon adenoma cell line, VACO-330. Functional studies demonstrate VACO-330 growth is stimulated by exogenous TGF-alpha and is completely abolished by a blocking anti-EGF-R antibody. Autocrine stimulation of EGF-R by TGF-alpha is therefore required for growth of the adenoma cell line. Autocrine stimulation of EGF-R by TGF-alpha does not cause malignant transformation of the colonic epithelial cell. In normal and adenomatous human colon TGF-alpha, via either an autocrine or paracrine mechanism, is likely an important physiologic stimulant of epithelial proliferation.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/114000/114709/JCI90114709.pdf
PubMed reference number	2365825v1
Volume Number	86
Issue Number	1
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Subject Keyword	Adenoma Adenomatous colonic polyps Adrenergic alpha-Agonists Colon Carcinoma Colon structure (body structure) Contribution Growth Factor Receptors TGFA protein, human Transcript Transforming Growth Factors autocrine
Content Type	Text
Resource Type	Article

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