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Idiopathic inflammatory demyelinating diseases of the central nervous system: differentiating between acute disseminated encephalomyelitis and malignant multiple sclerosis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Haase, Claus G. Faustmann, Pedro Med. |
| Copyright Year | 1999 |
| Abstract | Multiple sclerosis (MS) is the most frequent demyelinating disorder of the central nervous system (CNS). However, at presentation, it is frequently difficult to differentiate between malignant MS (MMS) and other fulminant CNS demyelinating diseases like acute disseminated encephalomyelitis (ADEM). The literature contains many case reports of ADEM but few series. We report on four representative cases of acute demyelinating diseases, together with evaluation of treatment, course and follow-up. We also present clinical, laboratory, neuropathologic, neuroimaging and data on therapeutic options, including follow-up, in order to establish distinguishing characteristics of MMS and ADEM. Good clinical outcome from a postinfectious, monophasic episode, correlating with regressive demyelinating lesions on MRI, after more than 2 years differentiate best. Therapeutic efficacy, prior infection and initial MRI lesions seem to be of limited value. Despite the advances of neuroimaging and laboratory techniques, objective parameters are still missing, but findings on basic immunologic mechanisms of humoral and cellular response might provide further insight. Copyright 1999 Harcourt Publishers Ltd. |
| Starting Page | 221 |
| Ending Page | 226 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0967-5868(99)90507-6 |
| PubMed reference number | 10835172 |
| Journal | Medline |
| Volume Number | 6 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0967586899905076 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0967586899905076?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0967-5868%2899%2990507-6 |
| Journal | Journal of Clinical Neuroscience |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
