NDLI: Pharmacokinetics and tissue penetration of fluconazole in rabbits.

Please wait, while we are loading the content...

Pharmacokinetics and tissue penetration of fluconazole in rabbits.

Content Provider	Semantic Scholar
Author	Walsh, Thomas J. Foulds, Glenn Pizzo, Philip A.
Copyright Year	1989
Abstract	Fluconazole is a new bis-triazole antifungal compound which has in vivo and in vitro activity against Candida spp. and Cryptococcus neoformans and excellent penetration into cerebrospinal fluid. However, little is known about the penetration of fluconazole into tissue sites other than cerebrospinal fluid. We therefore studied by high-pressure liquid chromatography the penetration of fluconazole into nine different tissue sites at times of peak and trough concentrations in plasma in rabbits. Fluconazole penetrated into all tissue sites. Tissue/plasma concentration ratios were greater at time of trough concentrations in plasma than at times of peak concentrations in plasma. The finding that fluconazole penetrated into target organs commonly infected by Candida spp. and C. neoformans further supports the therapeutic potential of fluconazole for disseminated candidiasis or cryptococcosis in immunocompromised hosts.
Starting Page	29
Ending Page	33
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://aac.asm.org/content/33/4/467.full.pdf
PubMed reference number	2543281v1
Volume Number	33
Issue Number	4
Journal	Antimicrobial agents and chemotherapy
Language	English
Access Restriction	Open
Subject Keyword	Antifungal Agents Body tissue Candida albicans reaction wheal^3D post 50 ug Candida albicans ID:Diam:Pt:Skin:Qn Carmustine Cerebrospinal Fluid Cryptococcus neoformans Ab:Titr:Pt:Ser:Qn Fluconazole Infection by Cryptococcus neoformans Organ Systemic candidiasis Triazoles
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in