NDLI: Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2.

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Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2.

Content Provider	Semantic Scholar
Author	Reynolds, Clare M. Loscher, Christine E. Moloney, Aidan P. Roche, Helen M.
Copyright Year	2008
Abstract	Trans-vaccenic acid (TVA) is a natural trans fatty acid found in ruminant food produce. It is converted to the cis-9, trans-11 isomer of conjugated linoleic acid (c9, t11-CLA) by the action of stearoyl-CoA desaturase (SCD) in tissue. c9, t11-CLA has been associated with anti-inflammatory effects and also affects lipid metabolism. The aim of the present study was to determine if TVA is bioconverted to c9, t11-CLA in intestinal epithelial cells and to ascertain whether TVA has effects similar to c9, t11-CLA on markers of inflammation relevant to inflammatory bowel disease. The present study demonstrated that TVA treatment led to significant bioconversion into c9, t11-CLA in Caco-2 cells. Treatment with both TVA and c9, t11-CLA resulted in alteration of cellular fatty acid profile and SCD activity in the Caco-2 cell line. However, CLA, but not TVA, significantly modulated transcription of TNF-alpha, IL-12, IL-6 and production of IL-12 by these cells. Thus the present study established that TVA treatment can alter SCD desaturation indices and induce compositional changes in the fatty acid profile of the Caco-2 cell model of the human intestinal epithelium but this is not associated with functional effects on markers of the inflammatory response.
File Format	PDF HTM / HTML
DOI	10.1017/S0007114508894329
PubMed reference number	18275620
Journal	Medline
Volume Number	100
Issue Number	1
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/ECF0E64C0F12A1C3DDF638A09751AD8E/S0007114508894329a.pdf/cis9_trans11conjugated_linoleic_acid_but_not_its_precursor_transvaccenic_acid_attenuate_inflammatory_markers_in_the_human_colonic_epithelial_cell_line_caco2.pdf
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114508894329
Alternate Webpage(s)	https://doi.org/10.1017/S0007114508894329
Journal	The British journal of nutrition
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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