NDLI: Recent Advances in Visualizing Alzheimer's Plaques by Magnetic Reso- nance Imaging

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Recent Advances in Visualizing Alzheimer's Plaques by Magnetic Reso- nance Imaging

Content Provider	Semantic Scholar
Author	Braakman, Niels Buchem, Mark A. Van Schliebs, Reinhard
Copyright Year	2009
Abstract	Abstract: The presence of amyloid plaques in the brain is one of prominent histological features of Alzheimer's disease. However, imaging of amyloid plaques in vivo in humans is not yet feasible. Recent technical advances in high resolution magnetic resonance imaging (MRI) methods in mice have enabled not only the detection of amyloid plaques in vivo but also allowed to monitor the development of these plaques with age in the same animals. Further technical improvements to visualize small plaques at early stages at ultrahigh magnetic fields are underway. This review summarizes some of the current developments in visualizing AD plaques in vivo in mice and highlights their future impact on drug discovery. Fur-thermore potential application and challenges of translation of these methods for visualizing plaques in human are dis-cussed. Keywords: Magnetic resonance imaging (MRI), Alzheimer's disease (AD), amyloid plaque imaging, longitudinal study, trans-genic mouse. INTRODUCTION Alzheimer's disease (AD) is the most frequent neurode-generative disorder with no effective treatment or definitive antemortem diagnostic test. AD increases in incidence expo-nentially with age and is therefore emerging as a leading health problem as populations are constantly aging. The dis-ease is characterized by a disruption of the neuronal func-tion, progressive memory loss and gradual cognitive, func-tional and behavioral deterioration [1,2]. The presence of senile plaques and neurofibrillary tangles in the brain are the most prominent pathological features of AD and postmortem observation of both of these neuro-pathologies in histologi-cal sections is still necessary for final confirmation of AD. The ability to visualize either of these pathologies with an
File Format	PDF HTM / HTML
DOI	10.2174/157340509787354741
Alternate Webpage(s)	http://ssnmr.lic.leidenuniv.nl/files/ssnmr/publications/285%20Braakman.pdf
Alternate Webpage(s)	https://doi.org/10.2174/157340509787354741
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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