Pituitary adenylate cyclase-activating polypeptide rhythm in the rat pineal gland

Content Provider	Semantic Scholar
Author	Fukuhara, Chiaki Inouye, Shin-Ichi T. Matsumoto, Yoshio Tsujimoto, G. Schwarz. M. Masuo, Yoshinori
Copyright Year	1998
Abstract	Pituitary adenylate cyclase-activating polypeptide (PACAP) was recently demonstrated to stimulate melatonin synthesis in the rat pineal gland. Circadian rhythms of melatonin concentration are well known. However, it has not been clarified whether PACAP contents in the pineal gland show circadian rhythm. In this study, we measured PACAP contents in the rat pineal gland throughout the day under 12:12 h light-dark cycle or constant dark conditions. A significant fluctuation was observed in the PACAP content under light-dark conditions but not under constant darkness. On the other hand, the pituitary gland showed no significant variation throughout the day under either conditions. These observations suggest that PACAP may participate in the modulation of melatonin synthesis depending on light conditions in the pineal gland.
Starting Page	115
Ending Page	118
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/S0304-3940(98)00041-X
PubMed reference number	9507934
Journal	Medline
Volume Number	241
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S030439409800041X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S030439409800041X?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0304-3940%2898%2900041-X
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article