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Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene
| Content Provider | Semantic Scholar |
|---|---|
| Author | Colacino, Evelina Porcheddu, Andrea Halasz, Ivan Charnay, Clarence Delogu, Francesco Guerra, Rubén Ruiz Fullenwarth, Julien |
| Copyright Year | 2018 |
| Abstract | The eco-compatible, base- and waste-free, energy-efficient, low-environmental-impact, gram-scale, mechanochemical preparation of marketed drugs such as nitrofurantoin (Furantin©), dantrolene (Dantrium©) and their structurally related derivatives is herein reported. Not a drop of organic solvent was used for the entire process and high yields of pure compounds were obtained without post-reaction work-up. Hydrazones were stable in the presence of water and gaseous HCl, formed as by-products during the synthesis. Comparative mechanochemical experiments were performed using diverse milling devices and jar materials, the active pharmaceutical ingredients were analyzed by PXRD and green metrics are calculated. |
| Starting Page | 2973 |
| Ending Page | 2977 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c8gc01345d |
| Volume Number | 20 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c8/gc/c8gc01345d/c8gc01345d1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c8gc01345d |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
