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Renoprotective Effects of Hypoxylonol C and F Isolated from Hypoxylon truncatum against Cisplatin-Induced Cytotoxicity in LLC-PK1 Cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hwang, Buyng Su Lee, Dahae Choi, Pilju Choi, Seon-Jun Song, Bong Geun Kim, Taejung Song, Ji Hoon Kang, Ki Sung Ham, Jungyeob |
| Copyright Year | 2018 |
| Abstract | Although cisplatin is the standard platinum-based anticancer drug used to treat various solid tumors, it can cause damage in normal kidney cells. Protective strategies against cisplatin-induced nephrotoxicity are, therefore, clinically important and urgently required. To address this challenge, we investigated the renoprotective effects of Hypoxylontruncatum, a ball-shaped wood-rotting fungus. Chemical investigation of the active fraction from the methanol extract of H.truncatum resulted in the isolation and identification of the renoprotective compounds, hypoxylonol C and F, which ameliorated cisplatin-induced nephrotoxicity to approximately 80% of the control value at 5 μM. The mechanism of this effect was further investigated using hypoxylonol F, which showed a protective effect at the lowest concentration. Upregulated phosphorylation of p38, extracellular signal-regulated kinases, and c-Jun N-terminal kinases following cisplatin treatment were markedly decreased after pre-treatment with hypoxylonol F. In addition, the protein expression level of cleaved caspase-3 was significantly reduced after co-treatment with hypoxylonol F. These results show that blocking the mitogen-activated protein kinase signaling cascade plays a critical role in mediating the renoprotective effect of hypoxylonol F isolated from H.truncatum fruiting bodies. |
| File Format | PDF HTM / HTML |
| DOI | 10.3390/ijms19040948 |
| PubMed reference number | 29565817 |
| Journal | Medline |
| Volume Number | 19 |
| Alternate Webpage(s) | https://res.mdpi.com/ijms/ijms-19-00948/article_deploy/ijms-19-00948-s001.pdf?attachment=1&filename= |
| Alternate Webpage(s) | http://www.mdpi.com/1422-0067/19/4/948/pdf |
| Alternate Webpage(s) | https://www.mdpi.com/1422-0067/19/4/948/pdf/1 |
| Alternate Webpage(s) | https://res.mdpi.com/ijms/ijms-19-00948/article_deploy/ijms-19-00948.pdf?attachment=1&filename= |
| Alternate Webpage(s) | https://doi.org/10.3390/ijms19040948 |
| Journal | International journal of molecular sciences |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
