NDLI: Highly stereoselective nickel-catalyzed difluoroalkylation of aryl ketones to tetrasubstituted monofluoroalkenes and quaternary alkyl difluorides† †Electronic supplementary information (ESI) available. CCDC 1565189 and 1880997. For ESI and crystallographic data in CIF or other electronic format see

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Highly stereoselective nickel-catalyzed difluoroalkylation of aryl ketones to tetrasubstituted monofluoroalkenes and quaternary alkyl difluorides† †Electronic supplementary information (ESI) available. CCDC 1565189 and 1880997. For ESI and crystallographic data in CIF or other electronic format see

Content Provider	Semantic Scholar
Author	Li, Chao Cao, Yi-Xuan Jin, Ruo-Xing Bian, Kang-Jie Qin, Zi-Yang Lan, Quan Wang, Xi-Sheng
Copyright Year	2019
Abstract	A nickel-catalyzed difluoroalkylation of α-C-H bonds of aryl ketones to furnish highly stereo-defined tetrasubstituted monofluoroalkenes or quaternary alkyl difluorides from secondary or tertiary ketones, respectively, has been established. Mechanistic investigations indicated that these C-H fluoroalkylations proceed via a Ni(i)/Ni(iii) catalytic cycle. An obvious fluorine effect was observed in the reaction, and this reaction has demonstrated high stereoselectivity, mild conditions, and broad substrate scopes, thus enabling the late-stage fluoroalkylation of bioactive molecules. This method offers a solution for expedient construction of monofluoroalkenes from readily available materials, and provides an efficient approach for the synthesis of bioactive fluorinated compounds for the discovery of lead compounds in medicinal chemistry.
Starting Page	9285
Ending Page	9291
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1039/C9SC02806D
Alternate Webpage(s)	https://pubs.rsc.org/en/content/articlepdf/2019/sc/c9sc02806d
PubMed reference number	32055314
Alternate Webpage(s)	https://doi.org/10.1039/C9SC02806D
Journal	Medline
Volume Number	10
Journal	Chemical science
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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