What roles does the organum vasculosum laminae terminalis play in fever in rabbits?

Content Provider	Semantic Scholar
Author	Hashimoto, Masaaki Ueno, Takehiko Iriki, Masami
Copyright Year	2007
Abstract	Experiments were designed to clarify the role of the brain's organum vasculosum laminae terminalis (OVLT) in the development of fever in rabbits. Rectal and ear skin temperatures were recorded in conscious animals in which the OVLT had been electrolytically destroyed or in which the preoptic anterior hypothalamus (PO/AH) had been transected bilaterally. When the OVLT had been ablated the febrile responses to intravenous injection of interleukin-1 beta (IL-1β) or tumour necrosis factor alpha were significantly attenuated, while those to intracerebroventricular injection of IL-1β were not affected. Fever induced by intracerebroventricular injection of prostaglandin E2 (PGE2) was prolonged significantly. The febrile responses to intravenous injection of IL-1β and to intracerebroventricular injection of PGE2 were attenuated when the transection was located caudally to the anterior wall of the third ventricle and extended laterally more than about 3 mm in the ventricular wall. The results show that the OVLT region is a site through which signals to increase body temperature are transferred from the blood to the brain in rabbits.
Starting Page	50
Ending Page	57
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1007/BF02584029
PubMed reference number	7708481
Journal	Medline
Volume Number	429
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/BF02584029
Alternate Webpage(s)	https://page-one.live.cf.public.springer.com/pdf/preview/10.1007/BF02584029
Alternate Webpage(s)	https://doi.org/10.1007/BF02584029
Journal	Pflügers Archiv
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article