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Prevalence of enteric hepatitis A and E viruses in the Mekong River delta region of Vietnam.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hien, Tran Tinh Tien, Nong Thi Khiem, Ha Ba Sac, Pham Kim Nhung, V. T. Larasati, Ria Purwita Laras, Kanti Putri, Maidy Doss, Robert Hyams, Kenneth Craig |
| Copyright Year | 1999 |
| Abstract | A study of antibody prevalence for hepatitis A virus (HAV) and hepatitis E virus (HEV) was carried out in southwestern Vietnam in an area adjacent to a known focus of epidemic HEV transmission. The purpose of this investigation was first to provide a prevalence measure of hepatitis infections, and second to determine the outbreak potential of HEV as a function of the susceptible population. Blood specimens collected from 646 persons in randomly selected village hamlets were examined by an ELISA for anti-HEV IgG and anti-HAV IgG. The prevalences of anti-HEV IgG and anti-HAV IgG were 9% and 97%, respectively. There was a significant increase (P < 0.01) in age-specific anti-HEV IgG. A notable increase in anti-HAV IgG prevalence (P < 0.0001) occurred between child populations 0-4 (64%) and 5-9 (95%) years of age. No evidence of familial clustering of anti-HEV IgG-positive individuals was detected, and household crowding was not associated with the spread of HEV. Boiling of water was found to be of protective value against HEV transmission. A relatively low prevalence of anti-HEV indicates considerable HEV outbreak potential, against a background of 1) poor, water-related hygiene/sanitation, 2) dependence on a (likely human/animal waste)-contaminated Mekong riverine system, and 3) periodic river flooding. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ajtmh.org/docserver/fulltext/14761645/60/2/10072151.pdf?accname=guest&checksum=1657ED43535B3A11D87AE2ED8BD534E8&expires=1542906950&id=id |
| PubMed reference number | 10072151v1 |
| Volume Number | 60 |
| Issue Number | 2 |
| Journal | The American journal of tropical medicine and hygiene |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Chemical and Drug Induced Liver Injury Enzyme-Linked Immunosorbent Assay Familial Mediterranean Fever Floods Hepatitis B Hepatitis E virus Low Prevalence Specimen Statistical Prevalence hepatitis A virus antibodies statistical cluster |
| Content Type | Text |
| Resource Type | Article |