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Prévalence de la Protéinurie et Facteurs Associés chez les Enfants et Adolescents Infectés par le VIH sous Traitement Antirétroviral à l'Hôpital Laquintinie de Douala, Cameroun
| Content Provider | Semantic Scholar |
|---|---|
| Author | Penda, Calixte Ida Moukoko, Else Carole Eboumbou Koum, Danièle Kedy Moudze-Kaptue, Béatrice Fetchouang, Franck Valles Keumoe Abomo, Olivia Evindi Eposse, Charlotte Bille, Bertrand Eyoum Mpondo, Emmanuel Mpondo Chiabi, Andreas |
| Copyright Year | 2018 |
| Abstract | RESUME Introduction. L’objectif de notre etude etait de determiner la prevalence de la proteinurie et ses facteurs associes chez les enfants infectes par le VIH. Methodes. Une etude transversale a ete conduite de janvier a juin 2016 a l’Hopital Laquintinie de Douala (HLD) chez les enfants et adolescents âges de 2 a 19 ans VIH positifs sous traitement antiretroviral (TARV). La proteinurie a ete systematiquement recherchee dans les urines des patients a l’aide de la bandelette reactive Combi screen 11, et une mesure quantitative de la creatinemie a ete faite lorsque la proteinurie etait positive. Les donnees ont ete analysees a l’aide du logiciel Starview version 5.0. et le seuil de significativite etait < 0,05. Resultats. Au total 300 enfants et adolescents VIH positifs ont ete recrutes ; leur âge median etait de 11 (IQ25-75%: 8-15) ans et le sex-ratio de 1,3/1. La prevalence de la proteinurie chez les enfants/adolescents infectes par le VIH sous TARV etait de 5% (15/300) et 86,66% (13/15) des enfants avec proteinurie presentaient une insuffisance renale legere a moderee avec une estimation du debit de filtration glomerulaire (eDFG) (30 a <90 ml/min/1,73 m2). La duree moyenne d’exposition sous TARV des patients etait de 78±41 mois et 53,33% des enfants etaient sous une tritherapie a base de Tenofovir en moyenne depuis 78 + 39 mois. La presence de la leucocyturie etait associee a la presence de la proteinurie de facon significative (OR= 4,33 IC 95% (1,46 – 12,86), p=0,008). Conclusion. La proteinurie est peu frequente, ce qui conforte le role de la nephroprotection induite par le TARV. Nos resultats suggerent l’importance de l’initiation precoce au TARV pour reduire la frequence de la proteinurie et le risque d’atteinte renale. ABSTRACT Introduction. The objective of our study was to determine the prevalence of proteinuria and its associated factors in HIV-infected children. Methods. A cross-sectional study was conducted from January to June 2016 at Douala Laquintinie Hospital (HLD) in HIV-positive children and adolescents aged 2-19 years on antiretroviral therapy (ART). Proteinuria was routinely investigated in the urine of patients using the Combi screen 11 test strip, and a quantitative measure of serum creatinemia was made when proteinuria was positive. The data was analyzed using Starview version 5.0 software. and the threshold of significance was <0.05. Results. A total of 300 HIV positive children and adolescents were recruited, the median age was 11 (IQ25-75%: 8-15 years) and the sex ratio was 1.3/1. The prevalence of proteinuria in HIV-infected children / adolescents on ART was 5% (15/300) and 86.66% (13/15) of children with proteinuria had mild to moderate renal impairment with an estimated glomerular filtration rate (eDFG) (30 to <90 ml/min /1.73 m2). The mean duration of ART exposure for patients was 78 ± 41 months and 53.33% of children were on triple therapy with Tenofovir on average for 78 + 39 months. The presence of leukocyturia was associated with the presence of proteinuria significantly (OR = 4.33 95% CI (1.46-12.86), p = 0.008). Conclusion. Proteinuria was uncommon in our study, reinforcing the role of ART-induced nephroprotection. Our results suggest the importance of early initiation of ART to reduce the frequency of proteinuria and the risk of kidney disease. |
| File Format | PDF HTM / HTML |
| Volume Number | 19 |
| Alternate Webpage(s) | http://www.hsd-fmsb.org/index.php/hsd/article/download/1093/pdf_642 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
