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Cardiogenic hypertension in maturing dogs.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Magrini, Fabio Roberts, Neil Branzi, Giovanna Mondadori, Caesar Reggiani, P. Ciulla, Michele M. Meazza, Roberto |
| Copyright Year | 1988 |
| Abstract | The purpose of this study was to evaluate whether the heart can induce high blood pressure by maintaining an inappropriately elevated cardiac output/body weight ratio during growth. Direct (femoral artery) mean arterial pressure (MAP), heart rate, cardiac output/body weight ratio (as defined by M-mode echocardiography), and total peripheral vascular resistance were measured and calculated every 2 months in nine conscious dogs during development from 2 to 10 months of age. In four dogs a J-shaped catheter for atrial pacing was chronically implanted at the age of 3 months, and their hearts were permanently paced at 130 beats/min until maturity. The aim of atrial pacing was to prevent the natural slowing of the heart rate and, consequently, to maintain a cardiac output/body weight ratio that was inappropriately high in relation to age during growth. Five dogs were studied as controls. No hemodynamic differences were observed until the age of 4 months. From the age of 5 to 10 months heart rate was kept at 130 beats/min by atrial pacing in the atrially paced group, and the mean cardiac output/body weight ratio did not decrease (196 +/- 24 vs 191 +/- 34 [SE] ml/min/kg). MAP rose from 62 +/- 4 to 116 +/- 8 mm Hg, and total peripheral resistance increased from 0.34 +/- 0.07 to to 0.61 +/- 0.09 mm Hg/ml/min/kg.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Starting Page | 295 |
| Ending Page | 300 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/12/3/295.full.pdf?download=true |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/12/3/295.full.pdf |
| Alternate Webpage(s) | https://air.unimi.it/retrieve/handle/2434/164407/160530/Hypertension%201988.pdf |
| PubMed reference number | 3169944v1 |
| Volume Number | 12 |
| Issue Number | 3 |
| Journal | Hypertension |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Canis familiaris Cardiac Output Echocardiography Heart Atrium Hemodynamics Hypertensive disease Implants Mercury Milliliter per Minute Premature ventricular contractions Pulmonary Hypertension Structure of femoral artery Total Peripheral Resistance beats per minute |
| Content Type | Text |
| Resource Type | Article |
