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Co-delivery of hydrophilic gemcitabine and hydrophobic paclitaxel into novel polymeric micelles for cancer treatment
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gao, Yunyun Gai, Xiumei Wang, Dun Wang, Yingying Yang, Xiaoguang Zhang, Dan Pan, Weisan Yang, Xinggang |
| Copyright Year | 2017 |
| Abstract | This study was carried out to investigate an effective method for the co-delivery of Gemcitabine (GEM) and paclitaxel (PTX) into tumor cells. GEM and PTX were modified with functional (+)-α-tocopherol (VE) to obtain similar water solubility. Folic acid-poly(ethylene glycol)–(+)-α-tocopherol (FA–PEG–VE) was designed to co-encapsulate the modified GEM and PTX. Methoxy poly(ethylene glycol)–poly(lactide-co-glycolide) (MPEG–PLGA) was used as a control. The characterizations of micelles were examined by DLS and TEM. It was found that two drugs-loaded FA–PEG–VE micelles, (GPF) and MPEG–PLGA micelles (GPM), had a spherical morphology with an average diameter of 127 nm and 118.9 nm, respectively. GEM–VE and PTX–VE encapsulation efficiencies of GPF were 91.09 ± 0.03%, 92.46 ± 0.02% (88.60 ± 0.03%, 89.32 ± 0.04% of GPM). In vitro release of GPF, 2.73% of GEM–VE and 2.88% of PTX–VE, were accumulatively released in 72 h (4.04% of GEM–VE and 3.88% of PTX–VE from GPM). Furthermore, comparisons of cytotoxicity were made with different fomulations. The IC50 of GPF after 72 h incubation was lowest. FA–PEG–VE micelle showed higher uptake efficiency than that of MPEG–PLGA micelle. Clathrin-mediated and energy-dependent endocytosis was involved in uptake mechanisms. These results demonstrated that GEM–VE and PTX–VE loaded FA–PEG–VE micelles would be a potentially useful prodrug-based nano-drug delivery system for cancer treatment. |
| Starting Page | 24030 |
| Ending Page | 24039 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C7RA02909H |
| Volume Number | 7 |
| Alternate Webpage(s) | https://pubs.rsc.org/en/content/articlepdf/2017/ra/c7ra02909h |
| Alternate Webpage(s) | http://pubs.rsc.org/en/content/articlepdf/2017/ra/c7ra02909h |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c7/ra/c7ra02909h/c7ra02909h1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C7RA02909H |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
