NDLI: Constructing Comparative Genome Maps with Unresolved Marker Order

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Constructing Comparative Genome Maps with Unresolved Marker Order

Content Provider	Semantic Scholar
Author	Goldberg, Debra McCouch, Susan R. Kleinberg, Jon M.
Copyright Year	2002
Abstract	Comparative genome maps are a powerful tool for interpreting the genomes of related organisms. The species maps which are the input to the process of constructing comparative maps are often themselves constructed from incomplete or inconsistent data, resulting in markers (or genes) whose order is not fully resolved. This incomplete marker order information is often handled by placing markers whose relative order cannot be reliably inferred together in a bin which is mapped to a common location. Previous automated and manual methods have handled such markers in an ad hoc or arbitrary way. We present efficient algorithms for comparative map construction that provide a principled method for handling unresolved marker order. The algorithms are based on a technique for efficiently computing a marker order that optimizes a natural parsimony criterion; in this way, they also yield a working hypothesis about the original incomplete data set.
Starting Page	1
Ending Page	6
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://helix-web.stanford.edu/psb02/goldberg.pdf
Alternate Webpage(s)	http://www.smi.stanford.edu/projects/helix/psb02/goldberg.pdf
Alternate Webpage(s)	http://www.cs.cornell.edu/home/kleinber/psb02.ps
Alternate Webpage(s)	http://www.cs.cornell.edu/Info/People/kleinber/psb02.ps
Alternate Webpage(s)	http://psb.stanford.edu/psb-online/proceedings/psb02/goldberg.pdf
PubMed reference number	11928470v1
Journal	Pacific Symposium on Biocomputing
Language	English
Access Restriction	Open
Subject Keyword	Bin Computation (action) Genome Handling (Psychology) Hoc (programming language) Inference Map Maximum parsimony (phylogenetics) Occam's razor Partial algorithm mapped
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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